This reflects the truth that, when the monograph program started, there was a "backlog" of agents for which strong proof of carcinogenicity had accumulated, and, naturally, these were the agents that IARC initially chosen for evaluation. Under the MAK carcinogenicity classification scheme, Category 4 carcinogens are substances with carcinogenic potential for which a non-genotoxic mode of motion is of prime importance and no important contribution human cancer risk is expected at exposures under the MAK (or BAT) value.
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Pulmonary and different well being effects of electronic cigarette use amongst grownup smokers collaborating in a randomized managed smoking reduction trial. 24. Notley C, Ward E, Dawkins L, Holland R.