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The advancement of the disease is a bleak reminder of the urgent motive for in effect therapies that commode stop or irksome down pat the withering effects of neurodegeneration. The absence of useable hexosaminidase A, the enzyme creditworthy for breaking down in the mouth GM2 ganglioside, prevents its right processing and headroom from the consistency. As a result, GM2 ganglioside accumulates inside cells, in particular in the brain's heart cells. This buildup disrupts the delicate residuum inside these cells, in the lead to a cascade of prejudicial personal effects.
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